Because diabetic nephropathy is characterized by excessive accumulation of ECM in the glomeruli, we next investigated the effect of miR-1207-5p and PVT1 over-expression and knockdown on the level of the two main regulators of ECM proteins, TGF-β1 and PAI-1 as well as one of the major components of ECM in MC: FN1. This evidence concerns the gene PVT1 and diabetic kidney disease.