Given the confirmatory results from several studies in multiple populations, the above hypothsis and the design of TaqMan probe, we focus on four polymorphisms, KIF1B rs17401966, STAT4 rs7574865, MICA rs2596542 and HLA-DQA/HLA-DQB rs9275572, to replicate in a HBV-related HCC case-control study among Chinese Han population. The gene discussed is HLA-DQB1; the disease is hepatocellular carcinoma.