Moreover, the potential mRNA target of miR-139-5p, nuclear receptor subfamily 5, group A, member 2 (NR5A2), which induces cell proliferation through the concomitant induction of cyclin D1 and E1 and promotes cancer invasion through the remodeling of the actin cytoskeleton and E-cadherin cleavage in cancer development and metastasis [17], [18], [19], [20], [21], was identified using 3′UTR luciferase reporter assay and correlation analysis with miR-139-5p expression in a population study, which provides insight into the mechanisms underlying miRNA deregulation in esophageal cancer. The gene discussed is NR5A2; the disease is esophageal cancer.