EGFR and neoplasm: We also noted that the combined inhibition of EGFR/HER2 with the EGFR/HER2 inhibitor lapatinib failed to substantially inhibit cell proliferation in cultured cell lines whereas when assessed in the orthotopic xenograft model, treatment with lapatinib and trametinib resulted in significantly enhanced inhibition of tumor growth relative to trametinib treatment alone.