CDH1 and signet ring cell carcinoma: Both S10 and S46 GC patients, having the ID 17 mutation, showed a reduction in the expression of E-cadherin and β-catenin by IHC analyses (Figure 5); the GC S10 patient, with a signet ring cell carcinoma, was diagnosed at the age of 61 years, and the GC S46 patient, with a diffuse adenocarcinoma, was diagnosed at the age of 58 years.