Female rats suffering ischemic cardiomyopathy were randomly assigned to 4 groups; intramyocardial injection of syngeneic male BMCs (BMC group), intramyocardial injection of male BMCs with anti-HMGB1 neutralizing antibody (AB group), intramyocardial injection of male BMCs with control IgG (IgG group), and intramyocardial injection of PBS only (CON group). Here, HMGB1 is linked to ischemic cardiomyopathy.