It is therefore plausible that TATI/SPINK1 and the interaction between TATI/SPINK1 and EGFR play different roles in CRC than in pancreatic cancer.Interestingly, expression of TATI/SPINK1 in cancer tissue is also associated with good prognosis in gastric cancer [37] and loss of TATI/SPINK1 expression correlates with aggressive disease in bladder cancer [38]. This evidence concerns the gene SPINK1 and urinary bladder cancer.