Statistically significant expression changes between tp0 and tp1 associated with inherited cancer predisposition (Mlh1+/-) and/or WD* were observed in seven genes (Table 4, Table S5); decreased expression in Dkk1 [Dickkopf homolog 1 (Xenopus laevis)], Slc5a8 [(Solute carrier family 5 (iodide transporter), member 8], Hoxd1 (Homeobox D1), and Socs1 (Suppressor of cytokine signalling 1), and increased expression in Dkk2 [Dickkopf homolog 2 (Xenopus laevis)], Rprm (Reprimo, TP53 dependent G2 arrest mediator candidate), and Acaa1b (acetyl-Coenzyme A acyltransferase 1B). The gene discussed is RPRM; the disease is cancer.