Four out of six neoplasias were found in the mice showing higher methylation at CGIs of all five genes Dkk1, Slc5a8, Hoxd1, Socs1 and Sfrp1 (B219, B220), of the four genes Dkk1, Hoxd1, Socs1 and Sfrp1 (B215), or of Dkk1 (B236) (Figure 2). The gene discussed is HOXD1; the disease is neoplasm.