The significance of WD* on CRC risk in our mouse series is highlighted by the fact that 5 out of 6 mice with neoplasias were fed with WD* and that WD* caused tumor development also in wild-type mice without inherited predisposition, i.e. the only carcinoma and one adenoma were found in the Mlh1+/+ WD* mice (Table 2, Figure S1). Here, MLH1 is linked to colorectal carcinoma.