Moreover, TNF-α plays an important role in the asthma physiopathology in humans and animals [49] acting as a chemotactic cytokine able to induce migration, proliferation and activation of leukocytes via a positive regulation of adhesion molecules expression such as VCAM-1 and ICAM-1, thus facilitating the cell migration [50,51]. The gene discussed is TNF; the disease is asthma.