Increased levels of lysyl oxidase (LOX), an amine oxidase critical for the initiation of collagen and elastin cross-linking [38], increased mRNA levels of collagen type I (Col1a2), collagen type III (Col3a1) and matrix metalloproteinase (Mmp2) have been reported in murine models of lung fibrosis [39]. This evidence concerns the gene ELN and pulmonary fibrosis.