Recently, Klimiuk PA et al. analyzed serum concentrations of soluble intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), and E-selectin (sE-selectin) in patients with early rheumatoid arthritis (RA) before and after 6 months of treatment with methotrexate (MTX). Here, SELE is linked to rheumatoid arthritis.