In addition to the involvement of these four pathways in RA, the associations between the four pathways and other autoimmune diseases also have been reported by previous pathway analyses, such as Cytokine-cytokine receptor interaction (hsa04060) in Crohn's disease (CD) [15], [33] and celiac disease (CeID) [36], Jak-STAT signaling pathway (hsa04630) in CD [15], [33], [34], T cell receptor signaling (hsa04660) in CD [34], Cell adhesion molecules (hsa04514) in CD [15], type 1 diabetes (TID) [15], [20] and multiple sclerosis (MS) [20], [35]. Here, SOAT1 is linked to multiple sclerosis.