We have previously shown that MBD2 is required for activation and maintaining a demethylated state of prometastatic genes in breast cancer [13] prostate cancer [14] and liver cancer [15] and that inhibition of MBD2 in colorectal and lung cancer cell lines reverses tumor growth as explants in vivo[16], [17] and overexpression of MBD2 leads to activation of Methylated TypeII Hexokinase Gene in hepatocytes [18]. Here, MBD2 is linked to liver cancer.