Strikingly, it has been recently reported that some members of the SR protein family of splicing factors and other components of the spliceosomal cellular machinery can actually act as oncoproteins and play a direct role in promoting tumor origin and progression [53–55] and that external stimuli such as hypoxia can cause the aberrant redistribution of important splicing factors such as Tra2 and promote the expression of tumor-promoting splicing isoforms [56]. The gene discussed is SLU7; the disease is neoplasm.