As mentioned above, mutations in three voltage-gated sodium channel subunits cause Brugada syndrome, the cardiac alpha subunit SCN5A, and accessory subunits SCN1B and SCN3B. Mutations in neuronal paralogs of the alpha subunit, SCN1A and SCN2A, had long ago been observed in rare cases of familial autism (Weiss et al., 2003) and prior to that had been shown to contribute dominant pathogenic alleles to the seizure syndrome GEFS+. The gene discussed is SCN1B; the disease is Brugada syndrome.