SCN1B and Brugada syndrome: While the Brugada syndrome associated sodium channel beta subunit locus SCN1B is well recognized to carry alleles that cause the GEFS+ seizure phenotype (Wallace et al., 1998) and can cause ASD together with this syndrome (Dixon-Salazar et al., 2004), no mutations in these accessory sodium channel subunits have yet been clearly associated with the ASD phenotype independent of seizures.