For example, the gene families (FHM1/CACNA1A, FHM2/ATP1A2 and FHM3/SCN1A), the mutational lesions and the integrated pathophysiology underlying FHM3, are all strikingly homologous to those in epilepsy, LQT and MHS, and provide a robust platform for understanding the pathogenesis of the calcium channel autism syndrome, TS/LQT8. The gene discussed is SCN1A; the disease is epilepsy.