THBS1 and thyroid cancer: BRAFV600E affects the expression of tumor extracellular matrix (ECM) non-cellular components [e.g., Thrombospondin-1 (TSP-1), integrins and others] (9) by regulating PTC cell microenvironment communications; indeed, the molecular action of BRAFV600E appears to affect both the migratory and invasive properties of the human thyroid cancer cell itself (10), as well as other cell types of the thyroid tumor microenvironment.