Orai1/STIM1 complex is implicated in breast, nasopharyngeal carcinoma, cervical and glioblastoma multiforme tumor cell migration in vitro and in a mouse model of metastases generated by tumor xenografts (Yang et al., 2009a; Chen et al., 2011; Motiani et al., 2013; Zhang et al., 2013). The gene discussed is ORAI1; the disease is neoplasm.