In this regard when considering TRPV4 potential role in tumor vascularization (Fiorio Pla et al., 2012b) it’s important to notice that TRPV4 is ubiquitary in healthy vascular endothelium and plays a physiological role both in large arteries and microvessels: these relevant activities require careful consideration of its therapeutic potential. The gene discussed is TRPV4; the disease is neoplasm.