Interestingly in lung cancer cells A549, EGF functionally regulates TRPM7 expression at the plasma membrane thus increasing cell migration rate (Gao et al., 2011) while TRPM7 protein downregulation significantly interferes with the metastatic potential of human breast cancer in vivo (Middelbeek et al., 2012). The gene discussed is TRPM7; the disease is breast carcinoma.