STIM1 is also a key player in EGF-mediated cervical cancer and nasopharyngeal carcinoma cell migration by inhibiting calpain activity and focal adhesion turnover (Chen et al., 2011; Zhang et al., 2013); STIM1 play also a role in stimulating angiogenesis by regulating VEGF-A release from cancer cells thus proposing a multiple function for STIM1 in tumor biology (Chen et al., 2011). This evidence concerns the gene STIM1 and neoplasm.