However a study from Schwab and co-workers has described a role for TRPV4 in hepatoblastoma cell line (HepG2): 4αPDD led predominantly to increased lamellipodial dynamics and velocity in HGF treated HepG2 cells, although the displacement, a measure of the cell persistence, was not statistically different from control conditions (Waning et al., 2007). The gene discussed is HGF; the disease is hepatoblastoma.