The inhibition of store-operated Ca2+ entry (SOCE) by a pharmacological agent, SKF96365, or by siRNA-mediated STIM1 or Orai1 silencing is able to inhibit MDA-MB- 231 cell migration and matrigel invasion, as well as reduce the spread of xenografted tumor cells in mice; on the other hand, reexpression of siRNA-resistant STIM1 or Orai1 constructs rescued the invasion of the STIM1 or Orai1 siRNA-treated cells. The gene discussed is ORAI1; the disease is neoplasm.