TRPM8 and Familial prostate cancer: Interestingly, the well-known prostate cancer marker, Prostate Specific Antigen (PSA) that is secreted in the prostatic acini and is therefore in contact with the extracellular part of TRPM8, activates the channel and decelerates cell migration by inducing its plasma membrane accumulation (Gkika et al., 2010) (Table 1; Figure 1).