However, a role for this bifunctional channel in cancer progression has been proposed only recently: TRPM7 is critical for cell migration of different cell cancer models such as breast cancer, lung cancer, nasopharingeal cancer and pancreatic ductal adrenocarcinoma (Chen et al., 2010; Gao et al., 2011; Middelbeek et al., 2012; Rybarczyk et al., 2012; Meng et al., 2013). The gene discussed is TRPM7; the disease is breast carcinoma.