TRPV2 and prostate neoplasm: Further it was shown that siRNA- mediated TRPV2 silencing reduces the size and invasive properties of xenografted prostate tumors in nude mice and downregulates the expression of MMP2, MMP9 and cathepsin B52, suggesting that TRPV2 is a viable pro-metastatic target in vivo (Monet et al., 2010) (Table 1; Figure 1).