CRP and type 2 diabetes mellitus: For example, Mendelian Randomization [5] studies have shown that variants within the CRP gene appear to be unrelated to hypertension, type 2 diabetes and coronary heart disease, suggesting that CRP is unlikely to be important in the aetiology of these conditions, but rather that observational associations between CRP and these diseases are more likely to represent confounding and/or reverse causation [6]–[8].