FTO and type 2 diabetes mellitus: Taken together these results suggest that the BMI-type 2 diabetes association does not solely reflect the effect of variants within FTO and other BMI genes known to be reliably associated with type 2 diabetes, and also further strengthens the proposition that genome-wide allelic scores may have promise in indexing intermediates, even in situations where there are no known variants underlying the intermediate (i.e. as we have artificially done here by removing the variants from the known BMI associated regions).