Our findings not only offer an important conceptual advance in our understanding of endometrial SRC-2 in peri-implantation biology but may well provide mechanistic underpinnings to explain the role of this coregulator in other areas of endometrial physiology (i.e. preterm labor [14]) as well as in endometrial pathophysiologies in women diagnosed with leiomyoma or polycystic ovary syndrome [13], [16]. Here, NCOA2 is linked to leiomyoma.