In particular, Sf3b1 mutations are prevalent in a wide range of hematologic malignancies, associated with 5% of acute myeloid leukemia cases, 10–15% of chronic lymphocytic leukemia cases, and 60–80% of the myelodysplastic syndrome subtype Refractory Anemia with Ring Sideroblasts (MDS-RARS) [57]–[68]. This evidence concerns the gene SF3B1 and myelodysplastic syndrome with single lineage dysplasia.