In particular, Sf3b1 mutations are prevalent in a wide range of hematologic malignancies, associated with 5% of acute myeloid leukemia cases, 10–15% of chronic lymphocytic leukemia cases, and 60–80% of the myelodysplastic syndrome subtype Refractory Anemia with Ring Sideroblasts (MDS-RARS) [57]–[68]. The gene discussed is SF3B1; the disease is B-cell chronic lymphocytic leukemia.