In addition, the fact that inhibition of CIITA and partial MHC II molecules (other MHCII could be impaired by vIRF-3 expression) in PBMC upon KSHV primary infection is in a LANA-dependent manner, supports the notion that both vIRF-3 and LANA participate in deregulation of MHC II molecules through different targets. Here, CIITA is linked to infection.