In contrast, suppression of LANA only led to a specific MHC II namely HLA-DQβ expression and presentation instead of HLA-DQα, DR or DP, as well as the evidence of vIRF3 inhibition further enhanced the HLA-DQβ expression caused by LANA suppression, indicating that LANA is directly involved with the deregulation of CD4+ T cells immune response against viral infection through cooperation with other viral antigen like vIRF3. This evidence concerns the gene HLA-DQB1 and viral infectious disease.