The results of quantitative PCR analysis showed that although the levels of all MHCII transcripts (HLA-DRα, HLA-DRβ, HLA-DPα, HLA-DPβ, HLA-DQα and HLA-DQβ) within 7-day post-infection consistently remained much less than that in the un-infected group (mock), there was a dramatic reduction of both CIITA pIII and pIV promoter-driven mRNA transcripts at 1-day post-infection and gradually decreased up to 7-days post-infection upon LANA expression with a more dramatic reduction seen at the pIV promoter (Figure 2A and B). The gene discussed is HLA-DPB1; the disease is infection.