In cells depleted of Tsg101, Hrs, or Rab7, we observed diminished co-localization between Mtb and LAMP1 and a concomitant increase in co-localization of Mtb with TfR compared to control cells 24 hours post-infection (hpi) (Figure 1B), suggesting decreased Mtb delivery to degradative compartments. This evidence concerns the gene HGS and infection.