Experimental infections with Candida albicans in IL-4 deficient mice led to impaired development of Th1 responses [38], and a Th1 promoting effect of IL-4 has also been observed in autoimmunity [36], [40], [74], tumor immunity [39], [75], [76] and contact sensitivity reactions [41], [77]. This evidence concerns the gene IL4 and Autoimmunity.