FAS and Glucose intolerance: Moreover, treatment of HFD-fed FasF/F and FasΔmye littermates with the TNFα blocking monoclonal antibody infliximab (Araujo et al, 2007), which recognizes both human as well as mouse TNFα epitopes (Qiu et al, 2011) abolished HFD-induced differences in glucose tolerance between both groups (Fig 6C) supporting the notion that circulating TNFα, induced by monocytic Fas, contributes to HFD-induced glucose intolerance.