As with chronic irradiation, PPARβ/δ expression and activity were enhanced in the skin of wild-type animals upon acute UV exposure, especially in the epithelial compartment where carcinomas arise, as documented by the stimulation of two known target genes, Tgfβ1 and Plin2 (Fig 1F) (supplementary Fig S2B). Here, PLIN2 is linked to carcinoma.