Given that PPARβ/δ is a promising molecular target in the prevention and treatment of metabolic diseases such as dyslipidemia, obesity and diabetes, we suggest a careful evaluation of the use of high-affinity PPARβ/δ agonists such as GW501516, which is currently in phase IV clinical trials for the treatment of dyslipidemia (Ooi et al, 2011). This evidence concerns the gene PPARD and Other metabolic disease.