PPARD and skin cancer: For example, Kim et al explored the anti-cancer properties of PPARβ/δ in skin using DMBA/TPA-induced carcinogenesis, a context in which tumour development was more severe in Pparβ/δ−/− mice than in wild-type animals, suggesting that PPARβ/δ attenuates the development of chemically induced skin cancer (Kim et al, 2004).