In this context, while some genetic alterations in cell cycle regulators, e.g., loss of cyclin-dependent kinase inhibitor 2A (CDKN2A) or RB function and CDK4 amplification, are associated with promoting glioma cell proliferation [9], changes in miRNA species modulate key nodes to similarly alter proliferative signaling pathways. Here, CDKN2A is linked to central nervous system cancer.