Aberrant activation of pro-angiogenic signaling pathways that are common in human cancers, e.g., the EGFR/phosphatidylinositol-3-kinase (PI3K)/Akt, vascular endothelial growth factor (VEGF), PDGF, and NF-κB pathways, is important in the development of neovessels in human gliomas [9,115,116,117,118]. The gene discussed is VEGFA; the disease is central nervous system cancer.