As a result, we have found that 1,25(OH)2D3 inhibits the expression of several β-catenin/TCF target genes such as c-MYC, TCF1, LEF1, AXIN2, PPARδ, CD44, ENC1 and EPHB2 in human colon cancer cells [35,39,40]. This evidence concerns the gene HNF4A and colonic neoplasm.