In vivo data also show that leptin induced IL-1R tI, VEGF and VEGFR2 as well as growth of breast tumors induced by a carcinogen, 7,12-dimethylbenz[a]anthracene (DMBA) in DIO mice [100] and was reported earlier in human breast cancer xenografts [102]. The gene discussed is IL1R1; the disease is breast carcinoma.