EGFR amplification at 7p12 is the most commonly amplified and over expressed gene in primary GBM (30%–70%) with EGFRvIII being the most prominent mutated receptor tyrosine kinase receptor in GBM, occurring in approximately 50% of GBM cases that overexpress EGFR [26]. The gene discussed is NTRK1; the disease is glioblastoma.