Data from gene expression profiling have indexed six key genes (NOB1, DDX47, IGSF2, LTB4R, SCARB1, and SLC25A3) which have been suggested to discriminate the initial and late stages of each clinical phase of CML [45], but their role in the progression of CML remains unknown. The gene discussed is SCARB1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.