KMT2A and acute myeloid leukemia: Acute myeloid leukemia (AML) with a normal karyotype (CN-AML), which accounts for 40–50% of AML cases, commonly presents with genetic mutations in ASXL1, MLL, DNMT3A, TET2, IDH1 and IDH2 genes, all of which have important roles in epigenetic regulation.