Acute and chronic malaria, in both rodent experimental models [22,23] and natural human disease [24], are, indeed, usually accompanied by a nonspecific PBA that is reflected by a marked increase in the concentration of immunoglobulins (IgM and IgG) and the presence of antibodies against antigens not related to the parasite, including auto-antigens, in the patient’s serum [25]. The gene discussed is CD40LG; the disease is malaria.