The purpose of the present study was to examine the possible association between the CR1 polymorphisms, Kn, McC, Sl and KCAM alleles, eight derived haplotypes and severity of malaria using samples from children between 0 and 15 years of age admitted to Korle-Bu Teaching Hospital in Accra, Ghana to confirm/disconfirm earlier studies. The gene discussed is CR1; the disease is malaria.