NF-1 is an autosomal dominant disorder affecting 1 in 3000 individuals, and is characterized by pigmented skin lesions (café au lait spots), cutaneous neurofibromas, tumors of the central and peripheral nervous system, and multiple skeletal abnormalities including scoliosis, local gigantism, subperiosteal bone cysts and tibial pseudarthrosis [1]. This evidence concerns the gene NF1 and Cafe-au-lait spot.