NF-1 is an autosomal dominant disorder affecting 1 in 3000 individuals, and is characterized by pigmented skin lesions (café au lait spots), cutaneous neurofibromas, tumors of the central and peripheral nervous system, and multiple skeletal abnormalities including scoliosis, local gigantism, subperiosteal bone cysts and tibial pseudarthrosis [1]. The gene discussed is NF1; the disease is neoplasm.