Another interesting observation based on this correlation analysis is that gonadal males and gonadal females exhibit opposite patterns of correlation for many genes; while Adcy1, Adcy2, Akt1, and Akt3 are negatively correlated with anxiety-like behavior in gonadal females, these same genes are positively correlated with anxiety-like behavior in gonadal males. This evidence concerns the gene ADCY1 and Anxiety.