The major findings of our study are – a) TGF-β1-induced EMT of NSCLC cells leads to increased resistance to both erlotinib and cisplatin; b) Hh signaling seems to play a role in such EMT-induced drug resistance because siRNA-mediated as well as pharmacological down-regulation of Hh signaling inhibits resistance to both the drugs and c) EMT regulating miRNAs such as miR-200b and let-7c are mechanistically involved in Hh signaling- and EMT-mediated resistance of NSCLC cells to TKI erlotinib. Here, TGFB1 is linked to non-small cell lung carcinoma.