CXCR3 and Granuloma: In mice models of granulomatous disease induced by Propionobacterium acnes, CXCL10 has been shown to be necessary for the formation of Th1 lymphocyte clusters in draining lymph nodes [27], and blockade of CXCR3 (the receptor for CXCL9 and CXCL10) and CCR5, inhibits the formation of granulomas in lungs [28].