We suspected different diagnoses such as Noonan syndrome, celiac disease, polyendocrine diseases for short stature, food allergies, hypereosinophilic syndromes, IPEX, autosomal-dominant hyperimmunoglobulin E syndrome and hyperimmunoglobulin E associated with Tyk2 deficiency. Here, TYK2 is linked to hyperinsulinemic hypoglycemia, familial, 4.