We suspected different diagnoses such as Noonan syndrome, celiac disease, polyendocrine diseases for short stature, food allergies, hypereosinophilic syndromes, IPEX, autosomal-dominant hyperimmunoglobulin E syndrome and hyperimmunoglobulin E associated with Tyk2 deficiency. The gene discussed is TYK2; the disease is immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome.