STAT3 and familial pancreatic carcinoma: Additionally, Kotha and coworkers reported that resveratrol inhibited Src and STAT3 signaling and induced apoptosis of malignant cells (NIH3T3/v-Src fibroblasts, human breast cancer MDA-MB-468 and MDA-MB-231, prostate cancer DU145, or human pancreatic cancer Panc-1 and Colo-357) containing activated STAT3 protein [98].