While some of the observations reported by others may not be clinically relevant, our results support the concept of necessity of additional insults for the alcoholic HCC development and are significant since alcohol-induced ER stress occurs in human alcoholics and emerging evidence has already demonstrated that polymorphic responses (SNPs) of BiP are associated with alcohol, HCC, and other types of cancer in the human population (Zhu et al., 2013). Here, HSPA5 is linked to hepatocellular carcinoma.