Particularly, the methylation of Derl3 and Herp was reduced in the tumor portion of older KOs, methylation of Creld2, Wfs, and Yod1 was not changed in the normal liver portion, and mRNA expression of Hrd1 and Yod1 was remarkably increased in both liver and tumor portions of KO with liver tumors. The gene discussed is WFS1; the disease is neoplasm.