After programmed electrical stimulation all transgenic animals developed sustained and lethal ventricular tachycardia (VT) or ventricular fibrillation (VF) and these effects were mainly caused by dysregulation of two downstream targets of miR-17-92, the lipid phosphatase and tensin homolog PTEN and Cx43 (Danielson et al., 2013). The gene discussed is PTEN; the disease is ventricular fibrillation.