This mouse model develops invasive pancreatic cancer based on the conditional expression of mutant K-ras (constitutively active mutation G12D) and mutant p53 (inactivating mutation R172H) in the pancreas, recapitulating human pancreatic cancer including prominent desmoplasia (Hingorani et al., 2005). The gene discussed is KRAS; the disease is familial pancreatic carcinoma.