As the NHE1 blocker amiloride is nonspecific and has off-target effects on glioma cells (Hegde et al., 2004), specific blockade of NHE1 with HOE642 (cariporide) confirmed a tonic activity for the NHE1 exchanger in glioma cell pHi regulation (Glunde et al., 2002). Here, SLC9A1 is linked to central nervous system cancer.