In order to shed light on the potential influence of components of the 53BP1 pathway on the BRCA1 predictive model, we retrospectively analyzed the expression levels of BRCA1, MDC1, CASPASE3, RNF8, UBC13, 53BP1, PIAS4, UBC9 and MMSET (Figure 1) in tumors from advanced NSCLC patients and correlated our results with outcome to first-line platinum-based chemotherapy. The gene discussed is NSD2; the disease is non-small cell lung carcinoma.