The volume and weight of tumor xenografts in nude mice were markedly decreased over 50 % of the negative control or untreated cell group at 20 days after inoculation with NET-1 shRNA cells (0.12 ± 0.02 g/192.50 ± 0.40 mm3, vs. 0.26 ± 0.42 g/295.19 ± 5.44 mm3 or 0.25 ± 0.12 g/276.00 ± 11.04 mm3) (P < 0.05) (Table 5). The gene discussed is NET1; the disease is neoplasm.