In conclusion, our results from human SSCC samples, A431 cell and nude mice model show that the main function of NET-1 gene as “molecular facilitators” may be involved in cell proliferation and migration, carcinoma differentiation and infiltration, tumor development and progress process and may play a tumor-related gene role, or as a candidate gene for diagnosis and a target gene for therapy of skin carcinomas. Here, NET1 is linked to neoplasm.