Tumor suppressor/oncogene ratio in the hubs associated with neuropathy network was 2:9 (APC and TGFB1 as tumor suppressors, ERK1/2, AKT, MYC, FOS, AP-1, BCL2L1, HSP70, HSP90, RELA being pro-growth and oncogenic, while the MAPK3, MAPK8 and MAPK14 were marked as having context dependent dual functions). This evidence concerns the gene MAPK8 and neoplasm.