RAF1 and neoplasm: This multifunctional profile lends itself to inhibition of tumors via the Ras/Raf/MEK pathway, activation and proliferation of endothelial cells via VEGFR-2 and the Ras/Raf/MEK pathway, recruitment of pericytes via PDGFR-β (required for vessel stabilization and maturity), recruitment of stabilizing stromal cells to the tumor’s parenchyma, as well as subsequent stimulation of stromal cells through growth factors[12-14].