In HCC rats treated with dsRNA, especially combination with sorafenib, the increase in the expressions of TLR3, NF-κB, caspase-8 and IFN-γ resulted in down-regulation of survivin, bcl-2 and PCNA, which indicates increased apoptosis and inhibition of tumor growth. Here, NFKB1 is linked to hepatocellular carcinoma.