However, HRM evaluation showed a significant increase in the average DNA methylation level in cancerous compared to histopathologically unchanged tissue from ninety patients with CRC in the CpG island of the PHD3 gene in regions chr14: 34 419 795–34 419 935 and chr14: 34 419 400–34 419 538 (p < 0.00001) (Figure 3B; Table 2, Additional file 1, Additional file 2). The gene discussed is EGLN3; the disease is colorectal carcinoma.