We found significantly lower levels of PHD1, PHD2 and PHD3 transcript (p = 0.00026; p < 0.00001; p < 0.00001) and protein (p = 0.004164; p = 0.0071; p < 0.00001) in primary cancerous than in histopathologically unchanged tissues in ninety patients with CRC (Figure 1A, B; Figure 2). The gene discussed is EGLN3; the disease is colorectal carcinoma.