TP53 and cancer: Cancer cells are known to establish a dynamic and well organized self-defensive anti-apoptotic strategy (“the neostrategy of cancer cells and tissues”) [27] which is mediated through different anti-acidifying mechanisms such as hyperactivity of the group of membrane-bound proton extrusion transporters, inactivation of Bcl-2, Bcl-xl and/or a pH-dependent de-stabilization of p53 [12,13,139].