The major causes of hyperhomocysteinemia include impairment of renal function, deficiencies of plasma folate, vitamin B12, and vitamin B6, and genetic factors, such as a genetic mutation (nucleotide C677T, alanine to valine substitution) in the enzyme methylenetetrahydrofolate reductase (MTHFR)[8,9]. This evidence concerns the gene MTHFR and hyperhomocysteinemia.