Moreover, exploratory adjusted Cox regression modeling revealed that women whose cancers overexpressed p53 protein, which reflects the presence of missense TP53 mutations, and expressed high THBS1 had a threefold elevation in the risk of disease progression and death compared with women whose cancers didn’t overexpress p53 or those that overexpressed p53 and expressed low THBS1 (9). The gene discussed is THBS1; the disease is cancer.